Acute Leukemias V: Experimental Approaches and Management of - download pdf or read online

By Leo Sachs (auth.), Prof. Dr. W. Hiddemann, Priv.-Doz. Dr. W. Plunkett, Prof. Dr. T. Büchner, Prof. Dr. J. Ritter, B. Wörmann M.D., Ph.D., M. J. Keating M.D., B.S., Prof. Dr. U. Creutzig (eds.)

ISBN-10: 3642789072

ISBN-13: 9783642789076

ISBN-10: 3642789099

ISBN-13: 9783642789090

This quantity, the 5th in a sequence on acute leukemias, focuses rather on contemporary easy examine effects and novel healing ways to the ailment. facets of leukemia mobilephone biology, together with differentiation, the mechanisms of drug resistance, the pharmacology of cytostatic brokers and the result of scientific trials in relapsed and refractory affliction are coated via notable foreign specialists within the respective fields. destiny advancements together with new brokers and new treatment plans reminiscent of unrelated bone marrow transplantation, immunotargeting and gene treatment entire a state of the art summery of present wisdom in experimental leukemia therapy.

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Extra info for Acute Leukemias V: Experimental Approaches and Management of Refractory Disease

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Acad. Sei. USA, 74: 253-257. 50. , Sachs, L. 1988. Deletion of ahorneobox gene in myeloid leukemias with a deletion in chromosome 2. Biochem. Biophys. Res. , 156: 1265-1270. 51. Sachs L. 1982. Normal development programmes in myeloid leukaemia. Regulatory proteins in the control of growth and differentiation. Cancer Surveys 1: 321-342. 52. Degos L. 1992. AIl-trans-retinoic aeid treatment and retinoic acid receptor alpha gene rearrangement in acute promyelocytic leukemia: a model for differentiation therapy.

In AML secondary to myelodysplasia 20 of 49 patients showed a significant percentage of stern celllike blasts. Immature blasts in RAEB-T and s-AML showed a continuous acquisition of the CD38 antigen. However, the relative distribution of blasts in the different steps of maturation differed considerably. The broad variations between cases were similar to primary AMi. In one patient with RAEB we repeated immunophenotyping after one year without clinical progression. The individual immunophenotype remained stable over this time period.

Acad. Sci. USA 72: 1744-1748. 17. , Sachs 1. 1989. Regulation of meagakaryocyte development by interleukin-6. Blood 74: 1545-1551. 18. Sachs 1. 1970. In vitro control of growth and development of hematopoietic cell clones. In: Regulation of Hematopoiesis, Vol. S. Gordon, ed. New York: Appleton-Century-Crofts, 217-233. 19. Sachs 1. 1974. Regulation of membrane changes, differentiation and malignancy in careinogenesis. Harvey Lectures, Vol. 68, New York: Academic Press, 1-35. 20. , Sachs 1. 1971.

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Acute Leukemias V: Experimental Approaches and Management of Refractory Disease by Leo Sachs (auth.), Prof. Dr. W. Hiddemann, Priv.-Doz. Dr. W. Plunkett, Prof. Dr. T. Büchner, Prof. Dr. J. Ritter, B. Wörmann M.D., Ph.D., M. J. Keating M.D., B.S., Prof. Dr. U. Creutzig (eds.)


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