Download e-book for iPad: Acne: Morphogenesis and Treatment by Gerd Plewig MD, Albert M. Kligman MD, PhD (auth.)

By Gerd Plewig MD, Albert M. Kligman MD, PhD (auth.)

ISBN-10: 3642962467

ISBN-13: 9783642962462

ISBN-10: 3642962483

ISBN-13: 9783642962486

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Heating the surface with an infra-red bulb will result in more sebum being collected by the cigarette paper method. This clearly makes sebum in the follicular reservoir more liquid causing it to flow out more swiftly. Such an effect is temporary and has no clinical significance. Some think that sebum production increases ten percent for every 1°C raise but the measurements are far too crude in our estimation to allow such precise formulation. Whether there are seasonal variations in sebum output has not been demonstrated beyond doubt.

This leads us to the more complicated question of whether cortisol might not have some indirect role in maintaining the sebaceous gland. This certainly seems to be the case in rats; adrenalectomized-castrated rats re- spond less well to testosterone than after simple castration. One way to look at this it to consider that cortisol has a permissive action. It permits testosterone to exert its full effect. It has been firmly demonstrated in animals that corticosteroids enhance the effect of testosterone on androgen sensitive targets such as the prostate and seminal vesicles.

J. invest. Derm. 62, 326-331 (1974). : Control of free fatty acids in human surface lipids by Corynebacterium acnes. 1. invest. Derm. 56, 127-131 (1971). : The skin microflora in acne vulgaris. J. invest. Derm. 62, 37-41 (1974). : Corynebacterium acnes and other anaerobic diphtheroids from human skin. J. Med. Microbiol. 7, 349-357 (1974). : Microbiology of comedones in acne vulgaris. J. invest. Derm. 60, 80-83 (1973). : Characteristics of the extracellular lipases from Corynebacterium acnes and Staphylococcus epidermidis.

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Acne: Morphogenesis and Treatment by Gerd Plewig MD, Albert M. Kligman MD, PhD (auth.)

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