By Karsten Schrör
Written via a number one specialist on Aspirin-related study, this can be the main entire treatise at the pharmacological results and scientific purposes of 1 of the main winning medications ever.
The textual content is written with a large viewers in brain, and to be comfortably comprehensible for clinicians, pharmacists, biomedical researchers and pharmacologists alike.
This moment, thoroughly revised version comprises the newest result of medical and pharmacological study on Acetylsalicylic acid, addressing the a number of pharmacological homes of this recognized drug with a balanced view on their translation into scientific perform, together with prevention from cardiovascular ailments and colorectal cancer.
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Extra info for Acetylsalicylic Acid
The classical assays are colorimetric assays, taking advantage from the intense red color of salicylate/ Fe3 þ complexes. The technology is simple and particularly suitable for compliance measurements. Trinder Method The Trinder method  is a colorimetric test where salicylic acid is determined by measuring the absorbance of the ferric ion–salicylate complex after total serum protein is precipitated by mercuric chloride and allowed to react with ferric iron supplied by ferric nitrate. This method involves the generation of a complex between salicylate and ferric ion.
The Journal of Clinical Investigation, 47, 2169–2180. B. and Peterson, J. (1968) Inhibition of adenosine diphosphate-induced secondary aggregation and other platelet functions by acetylsalicylic acid ingestion. Proceedings of the Society for Experimental Biology and Medicine, 127, 547–551. B. L. (1971) Aspirin selectively inhibits prostaglandin production in human platelets. Nature – New Biology, 231, 235–236. E. et al. (1991) Human platelet/erythroleukemia cell prostaglandin G/ H synthase: cDNA cloning, expression, and gene chromosomal assignment.
And Blume, H. (1988) Zur Qualit€atsbeurteilung von acetylsalizyls€aurehaltigen Fertigarzneimitteln. 2. Mitteilung: Untersuchung zur Chargenkonformit€at biopharmazeutischer Eigenschaften handels€ ublicher ASS-Pr€aparate. Pharmazeutische Zeitung Wissenschaft, 131, 21. 2 Determination of Salicylates Measurement of salicylates in biological ﬂuids, that is, mainly plasma and urine, is of interest for several purposes. The purpose also determines the selection of the method. Most frequent is the control of plasma levels to verify that the plasma concentrations are within the therapeutic range.
Acetylsalicylic Acid by Karsten Schrör